Signals governing the trafficking and mistrafficking of a ciliary GPCR, rhodopsin.

doi:10.1523/JNEUROSCI.1520-13.2013

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Article

Signals governing the trafficking and mistrafficking of a ciliary GPCR, rhodopsin.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Aug 2013

Lodowski Kerrie H, Lee Richard, Ropelewski Philip, Nemet Ina, Tian Guilian, Imanishi Yoshikazu

Abstract excerpt

Rhodopsin is a cilia-specific GPCR essential for vision. Rhodopsin mislocalization is associated with blinding diseases called retinal ciliopathies. The mechanism by which rhodopsin mislocalizes in rod photoreceptor neurons is not well understood. Therefore, we investigated the roles of trafficking signals in rhodopsin mislocalization. Rhodopsin and its truncation mutants were fused to a photoconvertible...

Topics

Amino Acid Sequence
Animals
Animals, Genetically Modified
Anura
Eye
Female
Gene Expression Regulation
Luminescent Proteins
Male
Models, Molecular
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Organ Culture Techniques

Photic Stimulation

Protein Binding

Protein Structure, Tertiary

Protein Transport

Receptors, G-Protein-Coupled

Retina

Source

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Identifiers

PMID: 23966685
DOI: 10.1523/JNEUROSCI.1520-13.2013
PMCID: PMC3755712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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