Towards a "Golden Standard" for computing globin stability: Stability and structure sensitivity of myoglobin mutants.

doi:10.1016/j.bbapap.2015.06.002

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Article

Towards a "Golden Standard" for computing globin stability: Stability and structure sensitivity of myoglobin mutants.

Biochimica et biophysica acta - 1 Oct 2015

Kepp Kasper P

Abstract excerpt

Fast and accurate computation of protein stability is increasingly important for e.g. protein engineering and protein misfolding diseases, but no consensus methods exist for important proteins such as globins, and performance may depend on the type of structural input given. This paper reports benchmarking of six protein stability calculators (POPMUSIC 2.1, I-Mutant 2.0, I-Mutant 3.0, CUPSAT, SDM, and mCSM)...

Topics

Algorithms
Animals
Benchmarking
Crystallography, X-Ray
Cytochromes c
Globins
Models, Molecular
Mutation
Myoglobin
Protein Conformation
Protein Engineering
Protein Stability
Software
Sperm Whale
Thermodynamics

Source

Open in PubMed

Identifiers

PMID: 26054434
DOI: 10.1016/j.bbapap.2015.06.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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