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Article

Toward Compilation of Balanced Protein Stability Data Sets: Flattening the ΔΔG Curve through Systematic Enrichment.

Journal of chemical information and modeling - 14 Mar 2022

Kebabci Narod, Timucin Ahmet Can, Timucin Emel

Abstract excerpt

Often studies analyzing stability data sets and/or predictors ignore neutral mutations and use a binary classification scheme labeling only destabilizing and stabilizing mutations. Recognizing that highly concentrated neutral mutations interfere with data set quality, we have explored three protein stability data sets: S2648, PON-tstab, and the symmetric Ssym that differ in size and quality. A characteristic...

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Mutation
Protein Stability
Proteins
Thermodynamics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35201762
DOI: 10.1021/acs.jcim.2c00054

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