Article
Self-consistency test reveals systematic bias in programs for prediction change of stability upon mutation.
Bioinformatics (Oxford, England) - 1 Nov 2018
Usmanova Dinara R, Bogatyreva Natalya S, Ariño Bernad Joan, Eremina Aleksandra A, Gorshkova Anastasiya A, Kanevskiy German M, Lonishin Lyubov R, Meister Alexander V, Yakupova Alisa G, Kondrashov Fyodor A, Ivankov Dmitry N
Abstract excerpt
Motivation: Computational prediction of the effect of mutations on protein stability is used by researchers in many fields. The utility of the prediction methods is affected by their accuracy and bias. Bias, a systematic shift of the predicted change of stability, has been noted as an issue for several methods, but has not been investigated systematically. Presence of the bias may lead to misleading results...
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