Article
Deconstructing the molecular portrait of basal-like breast cancer.
Trends in molecular medicine - 1 Nov 2006
Yehiely Fruma, Moyano Jose V, Evans Joseph R, Nielsen Torsten O, Cryns Vincent L
Abstract excerpt
Gene-expression profiling has revealed several molecular subtypes of breast cancer, which differ in their pathobiology and clinical outcomes. Basal-like tumors are a newly recognized subtype of breast cancer, which express genes that are characteristic of basal epithelial cells, such as the basal cytokeratins, and are associated with poor relapse-free and overall survival. However, the genetic and epigenetic...
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