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Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes

4 Jun 2015

Abstract excerpt

Aneuploidy in human eggs is the leading cause of pregnancy loss and several genetic disorders such as Down syndrome. Most aneuploidy results from chromosome segregation errors during the meiotic divisions of an oocyte, the egg's progenitor cell. The basis for particularly error-prone chromosome segregation in human oocytes is not known. We analyzed meiosis in more than 100 live human oocytes and identified an...

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PMID: 26045437
DOI: 10.1126/science.aaa9529

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