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Article

Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia.

Disease models & mechanisms - 1 Aug 2015

Liu Chao, Gates Keith P, Fang Longhou, Amar Marcelo J, Schneider Dina A, Geng Honglian, Huang Wei, Kim Jungsu, Pattison Jennifer, Zhang Jian, Witztum Joseph L, Remaley Alan T, Dong P Duc, Miller Yury I

Abstract excerpt

Apolipoprotein C-II (APOC2) is an obligatory activator of lipoprotein lipase. Human patients with APOC2 deficiency display severe hypertriglyceridemia while consuming a normal diet, often manifesting xanthomas, lipemia retinalis and pancreatitis. Hypertriglyceridemia is also an important risk factor for development of cardiovascular disease. Animal models to study hypertriglyceridemia are limited, with no...

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Source

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Identifiers

PMID: 26044956
DOI: 10.1242/dmm.019836
PMCID: PMC4527288

Genes

APOC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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