Article
Zebrafish are resilient to the loss of major diacylglycerol acyltransferase enzymes.
The Journal of biological chemistry - 1 Dec 2024
Wilson Meredith H, Hensley Monica R, Shen Meng-Chieh, Lu Hsiu-Yi, Quinlivan Vanessa H, Busch-Nentwich Elisabeth M, Rawls John F, Farber Steven A
Abstract excerpt
In zebrafish, maternally deposited yolk is the source of nutrients for embryogenesis prior to digestive system maturation. Yolk nutrients are processed and secreted to the growing organism by an extra-embryonic tissue, the yolk syncytial layer (YSL). The export of lipids from the YSL occurs through the production of triacylglycerol-rich lipoproteins. Here we report that mutations in the triacylglycerol synthesis...
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