Article

A high-cholesterol zebrafish diet promotes hypercholesterolemia and fasting-associated liver triglycerides accumulation

2023-11-04

Abstract excerpt

Zebrafish are an ideal model organism to study lipid metabolism and to elucidate the molecular underpinnings of human lipid-associated disorders. In this study, we provide an improved protocol to assay the impact of a high-cholesterol diet (HCD) on zebrafish lipid deposition and lipoprotein regulation. Fish fed HCD developed hypercholesterolemia as indicated by significantly elevated ApoB-containing lipoproteins (...

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Identifiers and source

Literature Corpus work: f08658ee-920a-53cc-8695-e71c2ddddbe6
DOI: 10.1101/2023.11.01.565134

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