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Article

Alternative strategies for optimizing treatment of chronic lymphocytic leukemia with complex clonal architecture.

Leukemia research - 1 Nov 2021

Smith Mitchell R, Cronin John F, Weiss Robert F

Abstract excerpt

In silico simulation of pre-clinical and clinical data may accelerate pre-clinical and clinical trial advances, leading to benefits for therapeutic outcomes, toxicity and cost savings. Combining this with clonal architecture data may permit truly personalized therapy. Chronic lymphocytic leukemia (CLL) exhibits clonal diversity, evolution and selection, spontaneously and under treatment pressure. We apply a...

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PMID: 34304129
DOI: 10.1016/j.leukres.2021.106663

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