Article
Autoimmune destruction of pancreatic beta cells.
American journal of therapeutics - 1 Jan 2000
Yoon Ji-Won, Jun Hee-Sook
Abstract excerpt
Type 1 diabetes results from the destruction of insulin-producing pancreatic beta cells by a beta cell-specific autoimmune process. Beta cell autoantigens, macrophages, dendritic cells, B lymphocytes, and T lymphocytes have been shown to be involved in the pathogenesis of autoimmune diabetes. Beta cell autoantigens are thought to be released from beta cells by cellular turnover or damage and are processed and...
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