Article
Genetic variation of hepatitis B virus and its significance for pathogenesis.
World journal of gastroenterology - 7 Jan 2016
Zhang Zhen-Hua, Wu Chun-Chen, Chen Xin-Wen, Li Xu, Li Jun, Lu Meng-Ji
Abstract excerpt
Hepatitis B virus (HBV) has a worldwide distribution and is endemic in many populations. Due to its unique life cycle which requires an error-prone reverse transcriptase for replication, it constantly evolves, resulting in tremendous genetic variation in the form of genotypes, sub-genotypes, and mutations. In recent years, there has been considerable research on the relationship between HBV genetic variation and...
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