Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior.

doi:10.1093/hmg/ddw334

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Article

Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior.

Human molecular genetics - 15 Dec 2016

Cornelis Marilyn C, Kacprowski Tim, Menni Cristina, Gustafsson Stefan, Pivin Edward, Adamski Jerzy, Artati Anna, Eap Chin B, Ehret Georg, Friedrich Nele, Ganna Andrea, Guessous Idris, Homuth Georg, Lind Lars, Magnusson Patrik K, Mangino Massimo, Pedersen Nancy L, Pietzner Maik, Suhre Karsten, Völzke Henry, Bochud Murielle, Spector Tim D, Grabe Hans J, Ingelsson Erik

Abstract excerpt

Caffeine is the most widely consumed psychoactive substance in the world and presents with wide interindividual variation in metabolism. This variation may modify potential adverse or beneficial effects of caffeine on health. We conducted a genome-wide association study (GWAS) of plasma caffeine, paraxanthine, theophylline, theobromine and paraxanthine/caffeine ratio among up to 9,876 individuals of European...

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PMID: 27702941
DOI: 10.1093/hmg/ddw334

Genes

ABCG2
AHR
GCKR
POR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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