Article
Genome-wide copy-number variation study of psychosis in Alzheimer's disease.
Translational psychiatry - 2 Jun 2015
Zheng X, Demirci F Y, Barmada M M, Richardson G A, Lopez O L, Sweet R A, Kamboh M I, Feingold E
Abstract excerpt
About 40-60% of patients with late-onset Alzheimer's disease (AD) develop psychosis, which represents a distinct phenotype of more severe cognitive and functional deficits. The estimated heritability of AD+P is ~61%, which makes it a good target for genetic mapping. We performed a genome-wide copy-number variation (CNV) study on 496 AD cases with psychosis (AD+P), 639 AD subjects with intermediate psychosis (AD...
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