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Article

Increased CNV-region deletions in mild cognitive impairment (MCI) and Alzheimer's disease (AD) subjects in the ADNI sample.

Genomics - 1 Aug 2013

Guffanti Guia, Torri Federica, Rasmussen Jerod, Clark Andrew P, Lakatos Anita, Turner Jessica A, Fallon James H, Saykin Andrew J, Weiner Michael, Vawter Marquis P, Knowles James A, Potkin Steven G, Macciardi Fabio

Abstract excerpt

We investigated the genome-wide distribution of CNVs in the Alzheimer's disease (AD) Neuroimaging Initiative (ADNI) sample (146 with AD, 313 with Mild Cognitive Impairment (MCI), and 181 controls). Comparison of single CNVs between cases (MCI and AD) and controls shows overrepresentation of large heterozygous deletions in cases (p-value<0.0001). The analysis of CNV-Regions identifies 44 copy number variable loci...

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Source

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Identifiers

PMID: 23583670
DOI: 10.1016/j.ygeno.2013.04.004
PMCID: PMC4012421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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