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Whole genome sequencing–based copy number variations reveal novel pathways and targets in Alzheimer's disease

17 Dec 2021

Abstract excerpt

INTRODUCTION: A few copy number variations (CNVs) have been reported for Alzheimer's disease (AD). However, there is a lack of a systematic investigation of CNVs in AD based on whole genome sequencing (WGS) data. METHODS: We used four methods to identify consensus CNVs from the WGS data of 1,411 individuals and further investigated their functional roles in AD using the matched transcriptomic and...

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PMID: 34918867
DOI: 10.1002/alz.12507

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