Article
Rare copy number variants in individuals at clinical high risk for psychosis: Enrichment of synaptic/brain-related functional pathways.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2020
Jagannath Vinita, Grünblatt Edna, Theodoridou Anastasia, Oneda Beatrice, Roth Alexander, Gerstenberg Miriam, Franscini Maurizia, Traber-Walker Nina, Correll Christoph U, Heekeren Karsten, Rössler Wulf, Rauch Anita, Walitza Susanne
Abstract excerpt
Schizophrenia is a complex and chronic neuropsychiatric disorder, with a heritability of around 60-80%. Large (>100 kb) rare (<1%) copy number variants (CNVs) occur more frequently in schizophrenia patients compared to controls. Currently, there are no studies reporting genome-wide CNVs in clinical high risk for psychosis (CHR-P) individuals. The aim of this study was to investigate the role of rare genome-wide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.