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Article

Therapeutically Targetable ALK Mutations in Leukemia.

Cancer research - 1 Jun 2015

Maxson Julia E, Davare Monika A, Luty Samuel B, Eide Christopher A, Chang Bill H, Loriaux Marc M, Tognon Cristina E, Bottomly Daniel, Wilmot Beth, McWeeney Shannon K, Druker Brian J, Tyner Jeffrey W

Abstract excerpt

Genome sequencing is revealing a vast mutational landscape in leukemia, offering new opportunities for treatment with targeted therapy. Here, we identify two patients with acute myelogenous leukemia and B-cell acute lymphoblastic leukemia whose tumors harbor point mutations in the ALK kinase. The mutations reside in the extracellular domain of ALK and are potently transforming in cytokine-independent cellular...

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Source

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Identifiers

PMID: 26032424
DOI: 10.1158/0008-5472.CAN-14-1576
PMCID: PMC4453002

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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