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Article

Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology.

Nature reviews. Cancer - 1 Oct 2013

Hallberg Bengt, Palmer Ruth H

Abstract excerpt

The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer (NSCLC). The common activation of ALK has led to the use of the ALK tyrosine kinase inhibitor (TKI) crizotinib in a range of patient populations and to the rapid development of second-generation drugs targeting ALK. In this Review, we discuss our...

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Source

Identifiers

PMID: 24060861
DOI: 10.1038/nrc3580

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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