Article
Molecularly targeted therapy in acute myeloid leukemia.
Annals of the New York Academy of Sciences - 1 Dec 2004
Bernasconi Paolo, Boni Marina, Cavigliano Paola Maria, Calatroni Silvia, Giardini Ilaria, Rocca Barbara, Zappatore Rita, Caresana Marilena, Quarna Jessica
Abstract excerpt
Meaningful progress has been made toward clarifying the molecular steps in the pathogenesis of acute myeloid leukemia (AML). Chromosome studies have established that translocations/inversions are the most common cytogenetic defects in AML. Cloning of chromosome breakpoints has shown that genes involved in the chromosome abnormalities are transcription factors, functional loss of which alters chromatin...
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