Article
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors.
Cancer research - 1 May 2008
McDermott Ultan, Iafrate A John, Gray Nathanael S, Shioda Toshi, Classon Marie, Maheswaran Shyamala, Zhou Wenjun, Choi Hwan Geun, Smith Shannon L, Dowell Lori, Ulkus Lindsey E, Kuhlmann Georgiana, Greninger Patricia, Christensen James G, Haber Daniel A, Settleman Jeffrey
Abstract excerpt
Selective kinase inhibitors have had a substantial impact on the field of medical oncology. Whereas these agents can elicit dramatic clinical responses in some settings, their activity is generally limited to a subset of treated patients whose tumor cells harbor a specific genetic lesion. We have established an automated platform for examining the sensitivity to various molecularly targeted inhibitors across a...
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