Fitness Consequences of Advanced Ancestral Age over Three Generations in Humans.

doi:10.1371/journal.pone.0128197

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Article

Fitness Consequences of Advanced Ancestral Age over Three Generations in Humans.

PloS one - 1 Jan 2015

Hayward Adam D, Lummaa Virpi, Bazykin Georgii A

Abstract excerpt

A rapid rise in age at parenthood in contemporary societies has increased interest in reports of higher prevalence of de novo mutations and health problems in individuals with older fathers, but the fitness consequences of such age effects over several generations remain untested. Here, we use extensive pedigree data on seven pre-industrial Finnish populations to show how the ages of ancestors for up to three...

Topics

Adult
Aged
Aged, 80 and over
Female
Finland
Humans
Longevity
Male
Middle Aged
Mutation
Pedigree
Sex Factors

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Identifiers

PMID: 26030274
DOI: 10.1371/journal.pone.0128197
PMCID: PMC4451146

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