Article
Mutation load and human longevity.
Mutation research - 9 Jun 1997
Gavrilov L A, Gavrilova N S, Kroutko V N, Evdokushkina G N, Semyonova V G, Gavrilova A L, Lapshin E V, Evdokushkina N N, Kushnareva Y E
Abstract excerpt
Since paternal age at reproduction is considered to be the main factor determining human spontaneous mutation rate (Crow, J. (1993) Environ. Mol. Mutagenesis, 21, 122-129), the effect of paternal age on human longevity was studied on 8,518 adult persons (at age 30 and above) from European aristocratic families with well-known genealogy. The daughters born to old fathers (50-59 years) lose about 4.4 years of their...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.