Article
Evolution, mutations, and human longevity: European royal and noble families.
Human biology - 1 Aug 1998
Gavrilova N S, Gavrilov L A, Evdokushkina G N, Semyonova V G, Gavrilova A L, Evdokushkina N N, Kushnareva Y E, Kroutko V N, Andreyev AYu
Abstract excerpt
The evolutionary theory of aging predicts that the equilibrium gene frequency for deleterious mutations should increase with age at onset of mutation action because of weaker (postponed) selection against later-acting mutations. According to this mutation accumulation hypothesis, one would expect the genetic variability for survival (additive genetic variance) to increase with age. The ratio of additive genetic...
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