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Article

Phosphorylation regulates FOXC2-mediated transcription in lymphatic endothelial cells.

Molecular and cellular biology - 1 Oct 2013

Ivanov Konstantin I, Agalarov Yan, Valmu Leena, Samuilova Olga, Liebl Johanna, Houhou Nawal, Maby-El Hajjami Hélène, Norrmén Camilla, Jaquet Muriel, Miura Naoyuki, Zangger Nadine, Ylä-Herttuala Seppo, Delorenzi Mauro, Petrova Tatiana V

Abstract excerpt

One of the key mechanisms linking cell signaling and control of gene expression is reversible phosphorylation of transcription factors. FOXC2 is a forkhead transcription factor that is mutated in the human vascular disease lymphedema-distichiasis and plays an essential role in lymphatic vascular development. However, the mechanisms regulating FOXC2 transcriptional activity are not well understood. We report here...

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Identifiers

PMID: 23878394
DOI: 10.1128/MCB.01387-12
PMCID: PMC3811871

Genes

FOXC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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