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Article

Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow

17 Mar 2020

Abstract excerpt

The atypical cadherin FAT4 has established roles in the regulation of planar cell polarity and Hippo pathway signaling that are cell context dependent. The recent identification of FAT4 mutations in Hennekam syndrome, features of which include lymphedema, lymphangiectasia, and mental retardation, uncovered an important role for FAT4 in the lymphatic vasculature. Hennekam syndrome is also caused by mutations in...

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PMID: 32182215
DOI: 10.1172/jci99027

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