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Repair synthesis step involving ERCC1-XPF participates in DNA repair of the Top1-DNA damage complex

29 May 2015

Abstract excerpt

Topoisomerase 1 (Top1) is the intercellular target of camptothecins (CPTs). CPT blocks DNA religation in the Top1-DNA complex and induces Top1-attached nick DNA lesions. In this study, we demonstrate that excision repair cross complementing 1 protein-xeroderma pigmentosum group F (ERCC1-XPF) endonuclease and replication protein A (RPA) participate in the repair of Top1-attached nick DNA lesions together with...

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PMID: 26025908
DOI: 10.1093/carcin/bgv078

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