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Article

Topoisomerase I as a biomarker: detection of activity at the single molecule level.

Sensors (Basel, Switzerland) - 10 Jan 2014

Proszek Joanna, Roy Amit, Jakobsen Ann-Katrine, Frøhlich Rikke, Knudsen Birgitta R, Stougaard Magnus

Abstract excerpt

Human topoisomerase I (hTopI) is an essential cellular enzyme. The enzyme is often upregulated in cancer cells, and it is a target for chemotherapeutic drugs of the camptothecin (CPT) family. Response to CPT-based treatment is dependent on hTopI activity, and reduction in activity, and mutations...

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Identifiers

PMID: 24434877
DOI: 10.3390/s140101195
PMCID: PMC3926610

Genes

TDP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24434877-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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