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Article

Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair.

The Journal of biological chemistry - 22 Jun 2012

Su Yan, Orelli Barbara, Madireddy Advaitha, Niedernhofer Laura J, Schärer Orlando D

Abstract excerpt

ERCC1-XPF is a heterodimeric, structure-specific endonuclease that cleaves single-stranded/double-stranded DNA junctions and has roles in nucleotide excision repair (NER), interstrand crosslink (ICL) repair, homologous recombination, and possibly other pathways. In NER, ERCC1-XPF is recruited to DNA lesions by interaction with XPA and incises the DNA 5' to the lesion. We studied the role of the four C-terminal...

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Source

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Identifiers

PMID: 22547097
DOI: 10.1074/jbc.M111.337899
PMCID: PMC3381147

Genes

ERCC1
XPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair.PMID 22547097Read ↗

Function and Interactions of ERCC1-XPF in DNA Damage ResponseSemantic proximity Read ↗

The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways.Semantic proximity Read ↗

Activity of individual ERCC1 and XPF subunits in DNA nucleotide excision repair.Semantic proximity Read ↗

The Structure of the Human ERCC1/XPF Interaction Domains Reveals a Complementary Role for the Two Proteins in Nucleotide Excision RepairSemantic proximity Read ↗

DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy.Semantic proximity Read ↗

Recruitment and positioning determine the specific role of the XPF-ERCC1 endonuclease in interstrand crosslink repair.Semantic proximity Read ↗

Mapping of interaction domains between human repair proteins ERCC1 and XPFSemantic proximity Read ↗

ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break RepairSemantic proximity Read ↗

ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients.Semantic proximity Read ↗

Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA.Semantic proximity Read ↗

The structure of the XPF-ssDNA complex underscores the distinct roles of the XPF and ERCC1 helix- hairpin-helix domains in ss/ds DNA recognition.Semantic proximity Read ↗

Repair protein persistence at DNA lesions characterizes XPF defect with Cockayne syndrome features.Semantic proximity Read ↗

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