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Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System

9 Jan 2014

Abstract excerpt

DNA repair and DNA damage checkpoints work in concert to help maintain genomic integrity. In vivo data suggest that these two global responses to DNA damage are coupled. It has been proposed that the canonical 30 nucleotide single-stranded DNA gap generated by nucleotide excision repair is the signal that activates the ATR-mediated DNA damage checkpoint response and that the signal is enhanced by gap enlargement...

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PMID: 24403078
DOI: 10.1074/jbc.m113.542787

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