Article
Transcriptome outlier analysis implicates schizophrenia susceptibility genes and enriches putatively functional rare genetic variants.
Human molecular genetics - 15 Aug 2015
Duan Jubao, Sanders Alan R, Moy Winton, Drigalenko Eugene I, Brown Eric C, Freda Jessica, Leites Catherine, Göring Harald H H, Gejman Pablo V
Abstract excerpt
We searched a gene expression dataset comprised of 634 schizophrenia (SZ) cases and 713 controls for expression outliers (i.e., extreme tails of the distribution of transcript expression values) with SZ cases overrepresented compared with controls. These outlier genes were enriched for brain expression and for genes known to be associated with neurodevelopmental disorders. SZ cases showed higher outlier burden...
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