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Article

Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes.

The Journal of pharmacology and experimental therapeutics - 1 Jan 2004

Murayama Norie, Soyama Akiko, Saito Yoshiro, Nakajima Yukiko, Komamura Kazuo, Ueno Kazuyuki, Kamakura Shiro, Kitakaze Masafumi, Kimura Hideo, Goto Yu-ichi, Saitoh Osamu, Katoh Masaaki, Ohnuma Teiichi, Kawai Mitsuru, Sugai Kenji, Ohtsuki Taisuke, Suzuki Chieko, Minami Narihiro, Ozawa Shogo, Sawada Jun-ichi

Abstract excerpt

Six novel nonsynonymous nucleotide alterations were found in the cytochrome P450 1A2 gene in a Japanese population, which resulted in the following amino acid substitutions: T83M, E168Q, F186L, S212C, G299A, and T438I. These individuals were heterozygous for the amino acid substitutions. The potential functional alterations caused by the amino acid substitutions were characterized by a cDNA-mediated expression...

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PMID: 14563787
DOI: 10.1124/jpet.103.055798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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