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Article

Functional characterization of 21 CYP2C19 allelic variants for clopidogrel 2-oxidation.

The pharmacogenomics journal - 1 Feb 2015

Takahashi M, Saito T, Ito M, Tsukada C, Katono Y, Hosono H, Maekawa M, Shimada M, Mano N, Oda A, Hirasawa N, Hiratsuka M

Abstract excerpt

Genetic variations in cytochrome P450 2C19 (CYP2C19) contribute to interindividual variability in the metabolism of therapeutic agents such as clopidogrel. Polymorphisms in CYP2C19 are associated with large interindividual variations in the therapeutic efficacy of clopidogrel. This study evaluated the in vitro oxidation of clopidogrel by 21 CYP2C19 variants harboring amino acid substitutions. These CYP2C19...

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Identifiers

PMID: 25001882
DOI: 10.1038/tpj.2014.30

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