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Article

MTHFR: Genetic variants, expression analysis and COMT interaction in major depressive disorder.

Journal of affective disorders - 1 Sept 2015

Gabriela Nielsen Maria, Congiu Chiara, Bortolomasi Marco, Bonvicini Cristian, Bignotti Stefano, Abate Maria, Milanesi Elena, Conca Andreas, Cattane Nadia, Tessari Elisabetta, Gennarelli Massimo, Minelli Alessandra

Abstract excerpt

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) genetic variations have been widely studied in major depressive disorder (MDD) and antidepressants outcome. An interaction with catechol-O-methyltransferase (COMT) has also been proved affecting depression. The aim of this study was to clarify the role of the most commonly studied single nucleotide polymorphisms (SNPs) of MTHFR gene in MDD and in treatment...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26021967
DOI: 10.1016/j.jad.2015.05.003

Genes

COMT
MTHFR
TRD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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