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Article

Depression and the role of genes involved in dopamine metabolism and signalling.

Progress in neurobiology - 1 Oct 2010

Opmeer Esther M, Kortekaas Rudie, Aleman André

Abstract excerpt

Major depressive disorder (MDD) is a common psychiatric disorder and leading cause of disability worldwide. It is associated with increased mortality, especially from suicide. Heritability of MDD is estimated around 40%, suggesting that genotyping is a promising field for research into the development of MDD. According to the dopamine theory of affective disorders, a deficiency in dopaminergic neurotransmission...

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Source

Identifiers

PMID: 20558238
DOI: 10.1016/j.pneurobio.2010.06.003

Genes

COMT
DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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