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Article

Analysis of COMT gene (Val 158 Met polymorphism) in the clinical response to SSRIs in depressive patients of European origin.

Journal of affective disorders - 1 Feb 2006

Arias Bárbara, Serretti Alessandro, Lorenzi Cristina, Gastó Cristóbal, Catalán Rosa, Fañanás Lourdes

Abstract excerpt

INTRODUCTION AND OBJECTIVES: There is convincing evidence of interactions between serotonergic and dopaminergic systems and it seems that an increase of dopamine concentration in the whole brain could be a limiting factor for the antidepressant like effect of antidepressants. The COMT gene might be a good candidate for explaining some aspects of the pharmacological response to SSRIs. METHODS: The aim of our study...

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Source

Identifiers

PMID: 16356553
DOI: 10.1016/j.jad.2005.11.008

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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