Article
Inflammatory molecules in Frontotemporal Dementia: cerebrospinal fluid signature of progranulin mutation carriers.
Brain, behavior, and immunity - 1 Oct 2015
Galimberti D, Bonsi R, Fenoglio C, Serpente M, Cioffi S M G, Fumagalli G, Arighi A, Ghezzi L, Arcaro M, Mercurio M, Rotondo E, Scarpini E
Abstract excerpt
Mutations in progranulin gene (GRN) are one of the major causes of autosomal dominant Frontotemporal Lobar Degeneration (FTLD). Progranulin displays anti-inflammatory properties and is likely a ligand of Tumor Necrosis Factor (TNF) receptor 2, expressed on microglia. A few cytokines and chemokines are altered in cerebrospinal fluid (CSF) from patients with sporadic FTLD, whereas no information is available in...
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