Article
[Histone deacetylase inhibitors cause the TP53-dependent induction of p21/Waf1 in tumor cells carrying mutations in TP53].
Tsitologiia - 1 Jan 2015
Kovalev R A, Shtam T A, Karelov D V, Burdakov V S, Volnitskiy A V, Makarov E M, Filatov M V
Abstract excerpt
p21/Waf1 protein is one of the main cell cycle arrest regulators and one of the most well-known transcriptional targets of TP53 protein. Here, we demonstrated the activation of expression of the p21/Waf1 gene when the cells were treated to sodium butyrate (NaBu)--one of the natural inhibitors of deacetylase, and investigated whether this phenomenon depends on the presence of functionally active TP53 protein. We...
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