Isolation of a mitomycin-resistant human lung adenocarcinoma cell subline to investigate the modulation by sodium butyrate of cell growth and drug resistance.

doi:10.1097/00001813-199312000-00003

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Article

Isolation of a mitomycin-resistant human lung adenocarcinoma cell subline to investigate the modulation by sodium butyrate of cell growth and drug resistance.

Anti-cancer drugs - 1 Dec 1993

Dong Q G, Gong L L, Wang H J, Wang E Z

Abstract excerpt

We developed a mitomycin C (MMC)-resistant human lung adenocarcinoma cell subline, SPC-A1/DM4, from cloned SPC-A1/D13 parent cells by 1 h exposures to escalating concentrations of the drug over 17 months. A 5.9-fold resistance to MMC and a 3.8-fold cross-resistance to cisplatin were present in re...

Topics

Adenocarcinoma
Butyrates
Butyric Acid
Cell Division
Cell Survival
Cisplatin
DNA, Neoplasm
Drug Resistance
Flow Cytometry
Humans
Lung Neoplasms
Mitomycin
Phenotype
Tumor Cells, Cultured
Vincristine

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