Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Effects of p21WAF1/CIP1 gene introduction on a human lung cancer cell line with p53 mutation].

Zhonghua bing li xue za zhi = Chinese journal of pathology - 1 Aug 1999

Zhuo Y, Zhang B, Li T, Wang H, Li S, Hou L, Wu B

Abstract excerpt

OBJECTIVE: To study the effects of p21WAF1/CIP1 gene expression on the biological hehavior of cancer cells with p53 gene mutation. METHODS: Expression of p21 vehicle was constructed and introduced into a human lung cancer cell ling PG with p53 gene mutation, the morphological and growth characteristics of the transfectant were then analysed. The CDK4 and PCNA levels were evaluated and the response to genotoxic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cisplatin
Share to Cyclin-Dependent Kinase 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Cyclin-Dependent Kinases

Share to Cyclins

Share to DNA Fragmentation

Share to Microscopy, Electron

Share to Proliferating Cell Nuclear Antigen

Source

Identifiers

PMID: 11869537

Genes

CDK4
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Effects of p21WAF1/CIP1 gene introduction on a human lung cancer cell line with p53 mutation].PMID 11869537Read ↗

[Effects of overexpression of p21WAF1/CIP1 on the malignant phenotype and apoptosis of human hepatocellular carcinoma cells].Semantic proximity Read ↗

[The use of p53 as a tool for human cancer therapy].Semantic proximity Read ↗

The Cyclin-Dependent Kinase Inhibitor p21CDKN1A as a Target of Anti-Cancer DrugsSemantic proximity Read ↗

Endogenous p21WAF1/CIP1 status predicts the response of human tumor cells to wild-type p53 and p21WAF1/CIP1 overexpression.Semantic proximity Read ↗

[WAF1/CIP1/p21 gene in wild type p53 and mutant p53 human breast cancer cell lines in relation to its cytobiological features].Semantic proximity Read ↗

p21Waf1/Cip1 protects against p53-mediated apoptosis of human melanoma cellsSemantic proximity Read ↗

Expression of the cyclin dependent kinase inhibitor p21WAF1/CIP1 in oesophageal squamous cell carcinomas.Semantic proximity Read ↗

Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugsSemantic proximity Read ↗

[Roles of mutant p53 gene in malignant phenotypes and resistance to drugs in anti-7,8-dihydrodiol-9,10-epoxide benzo(a)pyrene-induced lung cancer cells].Semantic proximity Read ↗

Stable low-level expression of p21WAF1/CIP1 in A549 human bronchogenic carcinoma cell line-derived clones down-regulates E2F1 mRNA and restores cell proliferation controlSemantic proximity Read ↗

Effects of p21cip1/waf1 overexpression on growth, apoptosis and differentiation in human colon carcinoma cells.Semantic proximity Read ↗

[Effect of mouse p53 minigene on lung cancer cells with different 172 structures regulated by tetracycline].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.