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Article

Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms.

Scientific reports - 10 Mar 2016

Asai Takashi, Hatlen Megan A, Lossos Chen, Ndiaye-Lobry Delphine, Deblasio Anthony, Murata Kazunori, Fleisher Martin, Cortizas Elena M, Verdun Ramiro E, Petrini John, Nimer Stephen D

Abstract excerpt

Multiple myeloma is a plasma cell neoplasm with an extremely variable clinical course. Animal models are needed to better understand its pathophysiology and for preclinical testing of potential therapeutic agents. Hematopoietic cells expressing the hypermorphic Rad50(s) allele show hematopoietic failure, which can be mitigated by the lack of a transcription factor, Mef/Elf4. However, we find that 70% of...

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Identifiers

PMID: 26961797
DOI: 10.1038/srep22760
PMCID: PMC4785351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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