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Characterization of rare germline variants in familial multiple myeloma

13 Feb 2021

Abstract excerpt

Multiple myeloma (MM) is a malignancy of plasma cells, characterized by the presence of monoclonal immunoglobulin, known as M protein 1 . MM is preceded by monoclonal gammopathy of undetermined significance (MGUS) which is also a precursor of immunoglobulin light chain (AL) amyloidosis 1 . Previous studies have reported a 2- to 4-fold increased risk of MGUS or MM in first-degree relatives of MM or MGUS patients,...

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PMID: 33583942
DOI: 10.1038/s41408-021-00422-6

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