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A novel in vitro assay to predict neonatal Fc receptor-mediated human IgG half-life

27 May 2015

Abstract excerpt

Immunoglobulin G (IgG) has an unusually long serum half-life in comparison to proteins of a similar size. It is well-known that this phenomenon is due to IgG's ability to bind the neonatal Fc receptor (FcRn) in a pH-dependent manner. FcRn binding properties can vary among IgGs, resulting in altered in vivo half-lives, and therefore it would be beneficial to accurately predict the FcRn binding properties of...

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PMID: 26018774
DOI: 10.1080/19420862.2015.1054585

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