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Article

Evaluation of an FcRn affinity chromatographic method for IgG1-type antibodies and evaluation of IgG variants.

Bioanalysis - 1 Sept 2017

Cymer Florian, Schlothauer Tilman, Knaupp Alexander, Beck Hermann

Abstract excerpt

AIM: The neonatal Fc-receptor (FcRn) mediates long serum half-life of therapeutic IgG-type antibodies. This interaction represents a critical quality attribute in terms of pharmacokinetics and should be covered by respective quality control strategies. Antibodies are taken up by cells unspecifically and can bind to FcRn in early endosomes preventing lysosomal degradation and allowing release back into...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28901177
DOI: 10.4155/bio-2017-0109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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