Article
Altered Craniofacial and Bone Morphology in Hyperthyroid Knock-In Mice Carrying TSHR D633H and M453T Mutations.
Thyroid : official journal of the American Thyroid Association - 1 Aug 2026
Makkonen Kristiina, Määttä Jorma, Ivaska Kaisa K, Patyra Konrad, Melnyk Vladyslav, Linnossuo Veli, Ojala Johanna O, Ravi Rowmika, Jaeschke Holger, Undeutsch Hendrik J, Paschke Ralf, Kero Jukka
Abstract excerpt
BACKGROUND: Constitutively active mutations (CAMs) in the thyrotropin receptor (TSHR) are the major cause of nonautoimmune hyperthyroidism. TSHR is a key regulator of thyroid hormone synthesis, which is essential for skeletal formation, bone turnover, and craniofacial development. In addition to its role in thyroid hormone regulation, thyrotropin and its receptor have been proposed to independently influence bone...
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