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Q63, a novel DENV2 RdRp non-nucleoside inhibitor, inhibited DENV2 replication and infection

25 Jun 2018

Abstract excerpt

Dengue virus (DENV) annually infects 400 million people worldwide. Unfortunately, there is lack of widely protective vaccine or drugs against DENV. The viral RNA-dependent RNA polymerase (RdRp) of NS5 protein is highly conserved among different DENV subtypes, thus presenting itself as an attractive target for drug design. In the current research, SPRi was performed to screen compounds against DENV2 RdRp and 5(1 H...

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Insect symbiosis and bacterial influences
Mosquito-borne diseases and control
Viral Infections and Vectors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30518482
DOI: 10.1016/j.jphs.2018.06.012

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