Article

Mechanistic Insights into Dengue Virus Inhibition by a Clinical Trial Compound NITD-688

2024-12-15

Abstract excerpt

Dengue, caused by the dengue virus (DENV), presents a significant public health challenge with limited effective treatments. NITD-688 is a potent pan-serotype DENV inhibitor currently in Phase II clinical trials. However, its mechanism of action is not fully understood. Here, we present the molecular details of how NITD-688 inhibits DENV. NITD-688 binds directly to the nonstructural protein 4B (NS4B) with nanomola...

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Literature Corpus work: 0a87dc50-3856-555a-b4d0-84ac71895a3c
DOI: 10.1101/2024.12.15.628546

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