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Article

Sunitinib Treatment Exacerbates Intratumoral Heterogeneity in Metastatic Renal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2015

Stewart Grant D, O'Mahony Fiach C, Laird Alexander, Eory Lel, Lubbock Alexander L R, Mackay Alan, Nanda Jyoti, O'Donnell Marie, Mullen Peter, McNeill S Alan, Riddick Antony C P, Berney Daniel, Bex Axel, Aitchison Michael, Overton Ian M, Harrison David J, Powles Thomas

Abstract excerpt

PURPOSE: The aim of this study was to investigate the effect of VEGF-targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC). EXPERIMENTAL DESIGN: Multiple tumor samples (n = 187 samples) were taken from the primary renal tumors of patients with mccRCC who were sunitinib treated (n = 23, SuMR clinical trial) or untreated (n = 23, SCOTRRCC study)....

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PMID: 26015515
DOI: 10.1158/1078-0432.CCR-15-0207

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PBRM1
VHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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