Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

doi:10.1056/NEJMoa1113205

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Article

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

The New England journal of medicine - 8 Mar 2012

Gerlinger Marco, Rowan Andrew J, Horswell Stuart, Math M, Larkin James, Endesfelder David, Gronroos Eva, Martinez Pierre, Matthews Nicholas, Stewart Aengus, Tarpey Patrick, Varela Ignacio, Phillimore Benjamin, Begum Sharmin, McDonald Neil Q, Butler Adam, Jones David, Raine Keiran, Latimer Calli, Santos Claudio R, Nohadani Mahrokh, Eklund Aron C, Spencer-Dene Bradley, Clark Graham, Pickering Lisa, Stamp Gordon, Gore Martin, Szallasi Zoltan, Downward Julian, Futreal P Andrew, Swanton Charles

Abstract excerpt

BACKGROUND: Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. METHODS: To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy profiling on multiple spatially separated samples obtained from primary renal carcinomas and associated metastatic...

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PMID: 22397650
DOI: 10.1056/NEJMoa1113205
PMCID: PMC4878653

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