Article
Mitochondrial DNA D-loop AG/TC transition mutation in cortical neurons of mice after long-term exposure to nucleoside analogues.
Journal of neurovirology - 1 Oct 2015
Zhang Yulin, Wang Bishi, Liang Qi, Qiao Luxin, Xu Bin, Zhang Hongwei, Yang Sufang, Chen Jun, Guo Hongliang, Wu Jian, Chen Dexi
Abstract excerpt
With the wide application of combined antiretroviral therapy, the prognosis of human immunodeficiency virus (HIV)-1 infected patient has been significantly improved. However, long-term administration of antiretroviral drugs can result in various drug-associated toxicities. Among them, nucleoside analogues were confirmed to inhibit DNA polymerase gamma, resulting in mitochondrial toxicity. Our previous study...
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